Stelara safe after IL-12 antibody dispute

Antitumor Activity IL-12 Bioactivity and Demonstrates Protein Retains Antibody Specificity and A Single-Chain IL-12 IgG3 Antibody Fusion

Onm-7: Safe Pregnancy after ART

Background: The transition to parenthood is a period of intra- and interpersonal changes and may bring up unexpected problems. The first child's birth has a significant effect on marital relations because the relations change from dyadic to triadic. In general, marital relationships seem to be especially vulnerable during the transition to parenthood, and several studies have revealed a de...

Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18.

Interleukin-12 (IL-12) orchestrates acquired resistance in intracellular Leishmania donovani infection in the liver, inducing gamma interferon and, in turn, macrophage activation and parasite killing. Nevertheless, testing in IL-18(-/-) mice compared to wild-type mice and in IL-12p40(-/-) compared to IL-12p35(-/-) mice also suggested both early-acting (IL-18) and late-acting (IL-23) antileishma...

Targeting the IL-12/IL-23 axis

Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors and act as an al...

Sustained IL - 12